Current developments and future perspectives of nanotechnology in orthopedic implants: an updated review.

Orthopedic implants are the most commonly used fracture fixation devices for facilitating the growth and development of incipient bone and treating bone diseases and defects. However, most orthopedic implants suffer from various drawbacks and complications, including bacterial adhesion, poor cell proliferation, and limited resistance to corrosion. One of the major drawbacks of currently available orthopedic implants is their inadequate osseointegration at the tissue-implant interface. This leads to loosening as a result of immunological rejection, wear debris formation, low mechanical fixation, and implant-related infections. Nanotechnology holds the promise to offer a wide range of innovative technologies for use in translational orthopedic research. Nanomaterials have great potential for use in orthopedic applications due to their exceptional tribological qualities, high resistance to wear and tear, ability to maintain drug release, capacity for osseointegration, and capability to regenerate tissue. Furthermore, nanostructured materials possess the ability to mimic the features and hierarchical structure of native bones. They facilitate cell proliferation, decrease the rate of infection, and prevent biofilm formation, among other diverse functions. The emergence of nanostructured polymers, metals, ceramics, and carbon materials has enabled novel approaches in orthopaedic research. This review provides a concise overview of nanotechnology-based biomaterials utilized in orthopedics, encompassing metallic and nonmetallic nanomaterials. A further overview is provided regarding the biomedical applications of nanotechnology-based biomaterials, including their application in orthopedics for drug delivery systems and bone tissue engineering to facilitate scaffold preparation, surface modification of implantable materials to improve their osteointegration properties, and treatment of musculoskeletal infections. Hence, this review article offers a contemporary overview of the current applications of nanotechnology in orthopedic implants and bone tissue engineering, as well as its prospective future applications.

Med-SRNet: GAN-Based Medical Image Super-Resolution via High-Resolution Representation Learning.

High-resolution (HR) medical imaging data provide more anatomical details of human body, which facilitates early-stage disease diagnosis. But it is challenging to get clear HR medical images because of the limiting factors, such as imaging systems, imaging environments, and human factors. This work presents a novel medical image super-resolution (SR) method via high-resolution representation learning based on generative adversarial network (GAN), namely, Med-SRNet. We use GAN as backbone of SR considering the advantages of GAN that can significantly reconstruct the visual quality of the images, and the high-frequency details of the images are more realistic in the image SR task. Furthermore, we employ the HR network (HRNet) in GAN generator to maintain the HR representations and repeatedly use multi-scale fusions to strengthen HR representations for facilitating SR. Moreover, we adopt deconvolution operations to recover high-quality HR representations from all the parallel lower resolution (LR) streams with the aim to yield richer aggregated features, instead of simple bilinear interpolation operations used in HRNetV2. When evaluated on a home-made medical image dataset and two public COVID-19 CT datasets, the proposed Med-SRNet outperforms other leading edge methods, which obtains higher peak signal to noise ratio (PSNR) values and structural similarity (SSIM) values, i.e., maximum improvement of 1.75 and minimum increase of 0.433 on the PSNR metric for "Brain" test sets under 8× and maximum improvement of 0.048 and minimum increase of 0.016 on the SSIM metric for "Lung" test sets under 8× compared with other methods.

Surface Mechanism of Fe3+ Ions on the Improvement of Fine Monazite Flotation With Octyl Hydroxamate as the Collector.

Froth flotation of fine minerals has always been an important research direction in terms of theory and practice. In this paper, the effect and mechanism of Fe3+ on improving surface hydrophobicity and flotation of fine monazite using sodium octyl hydroxamate (SOH) as a collector were investigated through a series of laboratory tests and detection measurements including microflotation, fluorescence spectrum, zeta potential, and X-ray photoelectron spectroscopy (XPS). Flotation tests have shown that fine monazite particles (-26 + 15 µm) cannot be floated well with the SOH collector compared to the coarse fraction (-74 + 38 µm). However, adding a small amount of Fe3+ to the pulp before SOH can significantly improve the flotation of fine monazite. This is because the addition of Fe3+ promotes the adsorption of SOH and greatly improves the hydrophobicity of the monazite surface. This can result in the formation of a more uniform and dense hydrophobic adsorption layer, as shown by the fluorescence spectrum and zeta potential results. From the XPS results, Fe3+ reacts with surface O atoms on the surface of monazite to form a monazite-Osurf-Fe group that acts as a new additional active site for SOH adsorption. A schematic model was also proposed to explain the mechanism of Fe3+ for improving surface hydrophobicity and flotation of fine monazite using octyl hydroxamate as a collector. The innovative point of this study is using a simple reagent scheme to float fine mineral particles rather than traditional complex processes.